| Title | Name | Phone | E-Mail |
| General Information (Submit a Complaint) | N/A | (216) 664-2324 | N/A |
| Text Telephone (TTY/TDD) | N/A | (800) 750-0750 | N/A |
| Text Telephone (TTY/TDD) | N/A | 711 | N/A |
| Medical Director | Natalie Hinchcliffe D.O. | (216) 664-4370 | NHinchcliffe |
| Interim Commissioner of Air Quality | David Hearne | (216) 664-2178 | Dhearne |
| Commissioner of Environment | Brian Kimball | (216) 664-2188 | Bkimball |
| Commissioner of Health | Persis Sosiak | (216) 664-7414 | Psosiak |
| Office of Emergency Preparedness | Shaddy Swade | (216) 664-7081 | Sswade |
| City Council/Legislative Liaison/Special Events | Sandra Wood | (216) 664-4361 | Swood |
| Communications Officer | Adam Nation | (216) 664-2889 | Anation |
| Chief Epidemiologist | Katherine Romig | (216) 420-7743 | Kromig |
| Health Center Manager | Kathy Rothenberg-James | (216) 664-2362 | Krothenberg |
| MomsFirst | Lisa Matthews | (216) 664-4281 | Lmatthews |
| HIV/AIDS | Tammie Jones | (216) 420-8641 | Tjones |
| Nursing | Jeannie Brooks | (216) 664-3609 | Jbrooks |
| Public Records Request | Adam Nation | (216) 664-2889 | Anation |
| Human Resources | Nicole Evans | (216) 664-4356 | Nevans |
| HR Assistant Administrator | N/A | (216) 664-4699 | N/A |
| Mental Health and Substance Abuse | Persis Sosiak | (216) 664-7414 | Psosiak |
| Birth and Death Certificates | N/A | (216) 664-2317 | N/A |
| Registrar of Vital Statistics | Andrea Kacinari | (216) 664-2320 | Akacinari |
| J. Glen Smith Health Center | Kathy Rothenberg-James | (216) 249-4100 | Krothenberg |
| McCafferty Health Center | Kathy Rothenberg-James | (216) 651-5005 | Krothenberg |
| Chief of Computer Operations (CCO) | Gabriel Reyes | (216) 420-7951 | Greyes |
